AllvertaGlobal – A number of smokers are known not to have lung cancer even though the risk of this disease is quite high for smokers. Researchers say it is related to genetic factors.
Smoking activity is known to cause various diseases, ranging from heart attacks, impotence, and various types of cancer, one of which is lung cancer. In the United States, smoking is the cause of death from lung cancer with a percentage reaching 90 percent.
The safest way to avoid this disease of course by not smoking. But recently a study showed there is a group of people who still smoke, but the potential for lung cancer is very small.
Reported by Science Alert, among people who smoke but do not develop lung cancer, the researchers found a unique finding. The cells lining their lungs seemed less likely to mutate.
The findings suggest that DNA repair genes are more active in certain individuals. This can then protect the individual from developing cancer, even when cigarettes are smoked regularly.
The researchers’ study used genetic profiles taken from the bronchi of 14 smokers who had never smoked and 19 light, moderate, and heavy smokers.
Surface cells collected from the participants’ lungs were individually sequenced to measure mutations in their genomes.
“These lung cells persist for years, even decades, and thus can accumulate mutations with age and smoking,” said Simon Spivack, a pulmonary and epidemiologist at the Albert Einstein College of Medicine, as quoted by Science Daily.
“Of all the types of lung cells, this is the most likely to become cancerous,” he added.
According to the researchers, these findings clearly show that mutations in the human lung increase with age, and among smokers, the DNA damage that occurs is even more significant.
Tobacco smoking has long been linked to triggering DNA damage in the lungs, but a new study finds that not all smokers suffer the same fate.
The number of detectable cell mutations in lung cells increases with smoking, and possibly increases the risk of lung cancer. But according to the study, the increase in cell mutations stopped after 23 years of smoking one pack a day.
“The heaviest smokers don’t have the highest mutation burden,” Spivack said.
“Our data suggest these individuals may have survived so long even though they were heavy smokers because they succeeded in suppressing further mutation accumulation. The decrease in mutations could stem from these individuals having highly adept systems for repairing DNA damage or detoxifying cigarette smoke.” the lid.
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